Statement of the Problem: Globally, the prevalence of Chronic Kidney Disease (CKD) in children is reported to be approximately 18-58 per million children and more common in children older than 6 years than in those younger than 6 years. The mortality rate of children with CKD requiring Renal Replacement Therapy (RRT) is at least 30-fold higher than their age-matched peers, and the health outcomes are not improving with an expected lifetime expectancy for children 0-4 years of age receiving dialysis is only until 20 years. Children receiving dialysis suffer significant disruption to their daily routine and quality of life. Most of them suffered delayed growth, social isolation, fatigue, depression, poor school attendance, impaired cognitive development, and low self-esteem. This article aimed to systematically review the factors affecting quality of life (Qol) of children and adolescents with CKD receiving dialysis.
Methodology: Systematic computer searches were conducted using PubMed, PsycINFO, Science Direct and CINAHL databases covering the period January 2000 to December 2014. Data were analyzed and the results are presented using the conceptual model of Health Related Quality of Life by Wilson and Cleary.
Results: The review found information on factors affecting overall QoL of children with CKD receiving hemodialysis categorized as biological factors, symptoms experience, functional status and general health perception. The socio-demographic characteristics and environmental factors contributed to the Qol of children diagnosed with CKD.
Conclusion: Given the detrimental effects to physical, psychological, emotional and social wellbeing of this vulnerable age-group, understanding and addressing the associated factors affecting several domains are paramount to better, sustainable Qol of pediatric population. This multifactorial analysis brings greater challenge for the health care providers to conduct comprehensive assessment and provide holistic approach of treatment and care management.